High-Purity Sulfachloropyridazine (CAS 80-32-0) for R&D: Technical Specifications and Synthesis Uses
Sulfachloropyridazine (SCP)
is a prominent member of the sulfonamide class, characterized by the molecular
formula C10H9ClN4O2S and a molecular weight of 284.72.
As a chlorinated derivative of sulfapyridazine, SCP exhibits enhanced
lipophilicity and pharmacokinetic properties, making it a critical subject in
both veterinary pharmacology and environmental analytical chemistry. Finetech
Industry Limited provides high-purity Sulfachloropyridazine as a research-grade reagent intended
for laboratory synthesis and industrial applications.
Mechanism of Action and Antimicrobial
Spectrum
The primary mechanism of
Sulfachloropyridazine involves the competitive inhibition of the enzyme dihydropteroate synthase (DHPS).
By acting as a structural analogue of p-aminobenzoic acid (PABA), SCP disrupts the
biosynthesis of dihydrofolic acid in susceptible micro-organisms.
·
Bacteriostatic Profile: SCP is highly effective against a broad spectrum of Gram-positive
and Gram-negative bacteria, particularly Escherichia coli, Salmonella spp., and Pasteurella multocida.
·
Synergistic Potential: Research indicates that when combined with dihydrofolate reductase
inhibitors (such as Trimethoprim), SCP demonstrates a potent synergistic
effect, significantly lowering the Minimum Inhibitory Concentration (MIC)
required for pathogen suppression.
Key Research Applications
1. Veterinary Pharmacokinetics and
Metabolism
Sulfachloropyridazine is widely
documented in literature for its rapid absorption and distribution in livestock
models. According to studies published in the Journal of Veterinary Pharmacology and Therapeutics,
SCP is frequently utilized in research concerning the treatment of respiratory
and gastrointestinal infections in porcine and avian species.
2. Environmental Trace Analysis and
Remediation
Due to its prevalence in agricultural
runoff, SCP has become a "marker compound" in environmental
toxicology. Research in Science
of The Total Environment highlights the use of high-purity SCP standards
for:
·
Developing LC-MS/MS protocols for
detecting sulfonamide residues in wastewater.
·
Studying the photodegradation kinetics
and advanced oxidation processes (AOPs) required to neutralize antibiotic
contaminants in soil.
3. Material Science and Synthesis
In the realm of custom synthesis, the
chloropyridazine moiety of CAS 80-32-0 serves as a versatile building block for
creating novel coordination polymers and metal-organic frameworks (MOFs) with
potential catalytic properties.
Technical Specifications
Finetech Industry Limited ensures
rigorous quality control for all research-grade materials:
|
Property |
Specification |
|
CAS Number |
|
|
Purity |
95.0% |
|
Appearance |
Yellow powder |
|
Solubility |
Soluble in
acetone and dilute mineral acids |
Regulatory and Availability Note
As a leading supplier of R&D reagents and raw
materials for non-regulated
markets, Finetech Industry Limited prioritizes technical excellence and
comprehensive documentation. Please note that our products are intended
strictly for laboratory research and industrial synthesis. We provide detailed
Certificates of Analysis (COA) and MSDS to support your compliance and safety
protocols.
References (Authority Citations)
1.
Sussman, M. (2014). The Sulfonamides:
Molecular Mechanisms and Clinical Applications.
2.
Zhang, L., et al. (2021). "Sorption
and degradation of Sulfachloropyridazine in agricultural soils."
Environmental Pollution Journal.
3.
European Medicines Agency (EMA).
Technical Report on Sulfonamide Residue Limits in Food-Producing Animals.
Keywords
·
Primary Keywords: Sulfachloropyridazine CAS 80-32-0, Buy Sulfachloropyridazine
Research Grade, Finetech Industry Limited chemicals.
·
Secondary Keywords: Veterinary sulfonamides, Antibiotic trace analysis, C10H9ClN4O2S
molecular weight, Chemical reagents