Blebbistatin (CAS 856925-71-8): The Gold Standard Myosin II Inhibitor for Precision Research
In advanced life science research, the precision of your molecular tools dictates the reliability of your data. (-)-Blebbistatin (CAS No. 856925-71-8) is an essential, high-selectivity bioactive small molecule for scientists exploring the frontiers of cell biology, neuroscience, and mechanobiology.
Finetech Industry Limited specializes in supplying high-purity, research-grade (-)-Blebbistatin, ensuring your experiments are backed by consistent and reproducible results.
🔬 Chemical Profile & Specifications
The biological activity of Blebbistatin is highly dependent on its stereochemistry. As the active enantiomer, (-)-Blebbistatin offers superior potency compared to the racemic mixture.1
Property Specification
Chemical Name (-)-Blebbistatin
CAS Number 856925-71-8
Molecular Formula $C_{18}H_{16}N_{2}O_{2}$
Molecular Weight 292.33
Purity ≥98% (HPLC verified)
Solubility DMSO
⚙️ Mechanism of Action: How it Works
Unlike general inhibitors, (-)-Blebbistatin offers a sophisticated mode of action. It selectively targets non-muscle myosin II by stabilizing the myosin–ADP–Pi complex.
Force Inhibition: It prevents the power stroke, effectively "locking" the motor without detaching it from the actin.
Structural Integrity: It inhibits contractility without disrupting the underlying actin filament network.
Reversibility: Its effects can be washed out, allowing for dynamic, "start-stop" temporal studies of cellular tension.
🧬 Key Research Applications
1. Cell Biology & Cytoskeletal Dynamics
Investigate the fundamental forces of life. (-)-Blebbistatin is the preferred tool for studying:
Cytokinesis: Visualizing cell division and contractile ring formation.
Cell Migration: Understanding how cells crawl and adhere to 2D/3D matrices.
Morphology: Probing the relationship between actomyosin tension and cell shape.
2. Neuroscience & Developmental Biology
Mechanical tension is a primary driver of neural growth. Use this inhibitor to study:
Axon Guidance: How growth cones navigate through mechanical cues.
Synaptic Plasticity: The role of myosin in dendritic spine remodeling.
Morphogenesis: Tissue-level folding and development driven by cellular forces.
3. Mechanobiology & Tissue Engineering
In the era of organoids and "lab-on-a-chip" technology, controlling force is vital:
Traction Force Microscopy (TFM): Measuring the exact forces cells exert on substrates.
Stem Cell Differentiation: Exploring how substrate stiffness and internal tension dictate cell fate.
âś… Why Source from Finetech Industry Limited?
When you choose Finetech, you are choosing a partner dedicated to scientific excellence. Our (-)-Blebbistatin is characterized by:
Enantiomeric Purity: Guaranteed (-)-form for maximum biological efficacy.
Full Analytical Support: Every batch is shipped with NMR, MS, and HPLC reports.
Proven Stability: Optimized packaging to prevent light-sensitive degradation.
Global Logistics: Efficient, temperature-controlled shipping to research institutes and pharma labs worldwide
đź“– Recommended References
Straight, A. F. et al. Dissecting temporal and spatial control of cytokinesis. Science, 2003.
Kovács, M. et al. Mechanism of blebbistatin inhibition of myosin II. JBC, 2004.
Even-Ram, S. et al. Myosin II regulates cell migration and adhesion dynamics. Nature Cell Biology, 2007.
🚀 Order Now for Your Next Project
Ready to elevate your mechanobiology research? Contact Finetech Industry Limited today for a quote or technical consultation.
Keywords: Myosin II Inhibitor, (-)-Blebbistatin, CAS 856925-71-8, Actomyosin contractility, Cell biology reagents, Mechanobiology tools, Finetech Industry Limited.