6-Aminoquinolyl-N-Hydroxysuccinimidyl Carbamate (CAS 148757-94-2): Applications, Benefits, and Analytical Uses

What is 6-Aminoquinolyl-N-Hydroxysuccinimidyl Carbamate?

6-Aminoquinolyl-N-Hydroxysuccinimidyl Carbamate (AQC Reagent, CAS 148757-94-2) is a highly sensitive fluorescent derivatization reagent widely used for amino acid analysis, amine detection, proteomics research, metabolomics studies, and pharmaceutical quality control.

With the molecular formula C14H11N3O4 and molecular weight of 285.25 g/mol, AQC has become one of the most trusted labeling reagents for high-performance liquid chromatography (HPLC) and ultra-performance liquid chromatography (UPLC) applications.

The compound is commonly known by several synonyms, including:

  • AQC Reagent
  • AccQ.Fluor Reagent
  • 6-Aminoquinoline N-Succinimidyl Carbamate
  • 2,5-Dioxo-1-pyrrolidinyl 6-Quinolylcarbamate
  • AccQ-Tag Reagent

Key Advantages of AQC Reagent

Compared with traditional derivatization agents such as FMOC-Cl and PITC, 6-Aminoquinolyl-N-Hydroxysuccinimidyl Carbamate offers several analytical advantages:

High Sensitivity Detection

AQC provides excellent fluorescence response, enabling detection of amino acids and amines at femtomole and picomole levels.

Fast One-Step Derivatization

The reagent reacts rapidly with both primary and secondary amines under mild alkaline conditions, simplifying sample preparation procedures.

Low Background Interference

Unreacted reagent hydrolyzes to 6-aminoquinoline (AMQ), minimizing chromatographic interference and reducing the need for extensive cleanup steps.

Excellent Derivative Stability

AQC-derived amino acid complexes remain stable for extended periods, supporting reliable quantitative analysis and reproducible chromatographic results.

Applications of 6-Aminoquinolyl-N-Hydroxysuccinimidyl Carbamate

Amino Acid Analysis by HPLC and UPLC

AQC is extensively used for pre-column derivatization of amino acids prior to chromatographic analysis.

Typical applications include:

  • Protein hydrolysate analysis
  • Amino acid composition studies
  • Peptide characterization
  • Nutritional analysis
  • Biopharmaceutical quality control

Proteomics Research

Researchers use AQC labeling to improve detection sensitivity for amino acid profiling and protein characterization in complex biological samples.

Metabolomics and Polyamine Analysis

The reagent is widely applied in the quantification of:

  • Putrescine
  • Spermidine
  • Spermine
  • Other biologically important amines

These compounds serve as critical biomarkers in cancer research, cell proliferation studies, and metabolic pathway investigations.

Food and Feed Quality Testing

AQC-based analytical methods are routinely used to determine amino acid content in:

  • Feed grains
  • Animal nutrition products
  • Food ingredients
  • Agricultural products

Pharmaceutical and Clinical Analysis

The reagent supports analytical workflows for:

  • Intravenous nutrition solutions
  • Biologic products
  • Glycoprotein characterization
  • Pharmaceutical quality assurance

Technical Specifications

PropertySpecification
Product Name6-Aminoquinolyl-N-Hydroxysuccinimidyl Carbamate
CAS Number148757-94-2
Molecular FormulaC14H11N3O4
Molecular Weight285.25 g/mol
AppearanceLight yellow to off-white powder
Purity≥98%
ApplicationAmino Acid Derivatization
SolubilityDMSO, Acetonitrile, DMF

Why Choose Finetech Industry Limited?

Finetech Industry Limited supplies high-quality 6-Aminoquinolyl-N-Hydroxysuccinimidyl Carbamate for analytical laboratories, research institutions, pharmaceutical companies, and biotechnology organizations worldwide.

Our advantages include:

  • High-purity AQC reagent
  • Strict quality control procedures
  • HPLC and NMR verification
  • Reliable global supply
  • Competitive bulk pricing
  • Technical support for analytical applications

Whether you require research quantities or bulk supply, we can provide dependable sourcing solutions for your analytical and biopharmaceutical projects.

Frequently Asked Questions

What is AQC reagent used for?

AQC reagent is primarily used for amino acid analysis, amine derivatization, proteomics research, metabolomics studies, and HPLC fluorescence detection.

What are the advantages of AQC over FMOC-Cl?

AQC offers higher derivative stability, lower background interference, simplified sample preparation, and excellent fluorescence sensitivity.

Can AQC react with secondary amines?

Yes. 6-Aminoquinolyl-N-Hydroxysuccinimidyl Carbamate efficiently reacts with both primary and secondary amines.

Is AQC suitable for pharmaceutical analysis?

Yes. AQC is widely used in pharmaceutical quality control, biologics characterization, amino acid profiling, and analytical method development.

Order 6-Aminoquinolyl-N-Hydroxysuccinimidyl Carbamate (CAS 148757-94-2)

Finetech Industry Limited provides high-quality AQC Reagent for research, analytical, and industrial applications. Contact our team for product specifications, COA, SDS, pricing, and global shipping information.