High-Purity Ammonium Salicylate (CAS 528-94-9) for Pharmaceutical & Cosmetic Applications

Finetech Industry Limited supplies high-quality Ammonium Salicylate (monoammonium salicylate, C₇H₉NO₃, MW 155.15, CAS 528-94-9) intended for research, formulation development, and use as a functional reagent in pharmaceutical intermediate synthesis. Ammonium salicylate is a water-soluble crystalline ammonium salt of salicylic acid with well-documented roles both as a direct API-related material (topical salicylate applications) and as a versatile reagent/precursor in organic synthesis.

1. Chemical profile & handling

• Name: Ammonium salicylate (salicylate, monoammonium salt)
• Formula / MW: C₇H₉NO₃ / 155.15
• Appearance & solubility: Colorless crystalline powder; highly soluble in water/ethanol; decomposition ≈213 °C reported.

Recommended handling: store dry, sealed, at low temperature (4 °C for long-term), control exposure to moisture. Use standard PPE and follow MSDS guidance from your supplier. ChemScene

2. Roles in pharmaceutical intermediate synthesis — summary

Ammonium salicylate is used in three interrelated ways in synthetic workflows relevant to pharmaceutical intermediates:

1. Direct reagent / intermediate precursor — as a convenient, soluble source of the salicylate anion for transformations (e.g., conversion to salicylamide, ortho-hydroxybenzonitrile derivatives). FINETECH INDUSTRY LIMITED+1
2. Ammonium counterion & phase behavior modulator — the ammonium cation can improve aqueous solubility and enable specific reaction media or precipitation/crystallization behaviors beneficial for downstream isolation.
3. Precursor to metal-salicylate complexes / catalytic species — ammonium salicylate is widely used to prepare metal–salicylate coordination complexes (Fe, Ba, transition metals), which have been exploited as catalysts or catalyst precursors in oxidation, coupling and transfer reactions. Such metal–salicylate complexes can act as heterogeneous or homogeneous catalysts depending on preparation and support. SciSpace+1

3. Representative synthetic applications & literature evidence

A. Preparation of salicylamide and related intermediates

Industrial and patent literature describe use of ammonium salicylate as a feedstock or intermediate to prepare salicylamide (a common pharmaceutical intermediate) by reaction with ammonia/amide-forming reagents and dehydration steps. These processes leverage the high solubility of the ammonium salt and avoid direct handling of free salicylic acid in some process routes. Example process descriptions and patents are available that outline mass ratios, aqueous saturation, and dehydration/separation steps. FINETECH INDUSTRY LIMITED+1

Practical note: converting ammonium salicylate to amides or nitriles typically involves condensation/dehydration (e.g., with urea, sulfamic acid or other dehydrating agents) under controlled heating; process patents provide detailed stoichiometry and workup conditions for scale-up. Google Patents

B. Synthesis of ortho-hydroxybenzonitrile (salicylonitrile) and related intermediates

Guidechem / industrial resources indicate ammonium salicylate can be used as a precursor in routes to ortho-hydroxybenzonitrile and analogous intermediates, which themselves are building blocks for more complex APIs or agrochemical scaffolds. These transformations may proceed via amide/nitrile formation sequences from the salicylate backbone.

C. Formation of metal–salicylate complexes for catalysis

The literature contains multiple reports where ammonium salicylate is reacted with metal salts (Fe, Ba, rare-earths, transition metals) to generate metal–salicylate coordination complexes. These complexes have been characterized and used as catalysts or catalyst precursors in organic transformations (e.g., oxidation chemistry, condensation reactions, and as building blocks for heterogeneous catalysts). Preparation from ammonium salicylate is often convenient because the salt dissolves readily and reacts under mild conditions to give isolable complexes. SciSpace+1

Example: Fe(III)–salicylate clusters and related complexes have been synthesized from ammonium salicylate and metal nitrates; such complexes have magnetic and catalytic properties and can be tailored by choice of solvent, stoichiometry and counterions. SciSpace

D. Influence of ammonium salts on catalyst synthesis & properties

Broader catalytic literature shows ammonium salts (including ammonium counterions) significantly affect the synthesis and catalytic properties of oxide and microporous catalysts (e.g., TSiO types) — altering morphology, acidity and active site dispersion. This supports the practical role of ammonium salicylate not merely as a passive reagent but as a functional additive in catalyst preparation. ResearchGate

4. Mechanistic rationale (concise, evidence-based)

• As nucleophile/electrophile source: The salicylate anion readily participates in acylation, esterification and nucleophilic substitution steps when activated (e.g., via acid chlorides, dehydrating agents). This underpins its use as an intermediate in amide/nitrile formation.
• As complexing ligand: The ortho-hydroxy and carboxylate functionality of salicylate chelates metal centers to form stable coordination complexes; when these metal–salicylate complexes are used as catalysts, the ligand environment modulates redox and Lewis acidity properties relevant to catalysis. SciSpace
• As ammonium-mediated phase controller: The ammonium counterion improves aqueous solubility and salt formation/crystallization behavior, which can simplify separations or enable unique reaction media (e.g., aqueous or biphasic systems).

5. Application scope & recommended use cases (for R&D and process chemistry)

• API intermediate routes — use ammonium salicylate as a soluble salicylate source in amide and nitrile syntheses (salicylamide, salicylonitrile). Suitable for bench-to-pilot scale with documented patent precedents. FINETECH INDUSTRY LIMITED+1
• Catalyst precursor preparation — synthesize metal–salicylate complexes (Fe, Ba, RE, transition metals) as homogeneous/heterogeneous catalysts or precursors; optimize solvent and stoichiometry to tune catalyst properties. SciSpace+1
• Formulation & analytical standards — used in topical analgesic formulations and as QC reference material for salicylate-based products. PharmaCompass.com+1

6. Representative references & further reading (selected)

1. Finetech product/process note — ammonium salicylate application in salicylamide synthesis (process description). FINETECH INDUSTRY LIMITED
2. Patent CN110698362A / related process patents — continuous methods and dehydration/condensation routes using ammonium salicylate. Google Patents
3. SciSpace / journal reports on metal–salicylate cluster synthesis and properties (examples of Fe₃–oxo salicylate clusters). SciSpace
4. Reviews / method papers on preparation of metal salicylates and their catalytic uses (sol-gel & soft chemistry routes). Database & supplier technical pages (ChemicalBook, PharmaCompass, KeyOrganics) — physicochemical data and commercial grades.

7. Product & supply information (Finetech offering)

Finetech Industry Limited can supply research and industrial-grade Ammonium Salicylate (CAS 528-94-9, C₇H₉NO₃, MW 155.15) with certificate of analysis and technical documentation. Typical uses supported by our technical team: intermediate synthesis troubleshooting, metal–salicylate complex preparation, and formulation prototyping.

Contact: sales@finetechnology-ind.com

8. Suggested next steps for process chemists

1. Feasibility screen: run small-scale reactions converting ammonium salicylate to desired intermediates (amide/nitrile) under literature conditions cited in patents.
2. Catalyst preparation trials: prepare candidate metal–salicylate complexes (Fe, Cu, Ni) and evaluate activity in target transformations; characterize by IR, elemental analysis and, where relevant, XRD. SciSpace
3. Crystallization & isolation: exploit ammonium counterion for controlled crystallization to improve purity and downstream handling.

Brief summary

Ammonium Salicylate (CAS 528-94-9) is more than a cosmetic/topical raw material: its chemical properties make it a practical reagent and precursor in pharmaceutical intermediate synthesis and a convenient precursor to metal-salicylate catalytic species. The combination of aqueous solubility, chelating salicylate anion, and an easily handled ammonium counterion enables both synthetic convenience and catalytic versatility — attributes supported by patent literature and coordination chemistry reports. FINETECH INDUSTRY LIMITED+2Google Patents+2

Ordering & Supply Information

Finetech Industry Limited provides Ammonium Salicylate in high purity and stable supply chains, suitable for both laboratory and manufacturing environments.
Contact us for quotations, COA requests, or bulk supply discussions.

📧 sales@finetechnology-ind.com

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