Boc-Arg(Pbf)-OH Supplier – High-Purity Protected Arginine for Peptide Synthesis | CAS 200124-22-7 | Finetech Industry Limited

1. Product Overview

Boc-Arg(Pbf)-OH (CAS No. 200124-22-7) is a protected arginine derivative widely used in peptide chemistry and solid-phase peptide synthesis (SPPS). Also known as Nα-Boc-Nω-Pbf-L-arginine, this compound contains two important protecting groups: a tert-butoxycarbonyl (Boc) group protecting the alpha-amino group and a Pbf group protecting the guanidino side chain of arginine.

The combination of these protecting groups helps control the reactivity of arginine during peptide chain assembly. By temporarily protecting the amino and guanidino functionalities, Boc-Arg(Pbf)-OH supports the selective formation of peptide bonds and helps reduce unwanted side reactions associated with the highly functionalized arginine side chain.

As a valuable protected amino acid building block, Boc-Arg(Pbf)-OH is relevant to peptide synthesis, pharmaceutical research, peptide intermediate development, and related chemical research.

Finetech Industry Limited supplies Boc-Arg(Pbf)-OH (CAS 200124-22-7) with a specified purity of ≥98%, available in 100 g, 1 kg, 5 kg, and 25 kg packaging. Larger-scale production can also be discussed according to project requirements.

2. Product Specifications

3. Chemical Characteristics and Protecting Group Design

Boc-Arg(Pbf)-OH is a protected amino acid derivative designed for applications in peptide synthesis. Its molecular structure incorporates an arginine backbone and two protecting groups that serve different functions during synthetic operations.

Nα-Boc Protection

The Boc group protects the alpha-amino functionality of arginine. In peptide synthesis, temporary protection of the amino group helps control the sequence of peptide bond formation and supports selective coupling during chain assembly.

Nω-Pbf Side-Chain Protection

Arginine contains a guanidino group in its side chain, which is strongly basic and highly functional. The Pbf (2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl) group protects this side-chain functionality during peptide synthesis.

Side-chain protection is particularly important when preparing peptides containing arginine residues, as it helps prevent unwanted reactions involving the guanidino group during coupling and subsequent synthetic steps.

Complementary Protection Strategy

The Boc and Pbf groups provide complementary protection for different reactive sites within the arginine structure. This protection strategy makes Boc-Arg(Pbf)-OH a useful building block for controlled peptide assembly and the preparation of arginine-containing peptide sequences.

4. Research Applications of Boc-Arg(Pbf)-OH

4.1 Solid-Phase Peptide Synthesis (SPPS)

Boc-Arg(Pbf)-OH is used as a protected amino acid building block in solid-phase peptide synthesis. The protected alpha-amino group supports controlled peptide chain elongation, while Pbf protection helps keep the arginine side chain from participating in unwanted reactions during synthesis.

It is particularly relevant to peptide sequences that contain one or multiple arginine residues.

4.2 Preparation of Arginine-Containing Peptides

Arginine is an important amino acid found in many biologically active peptides and peptide research candidates. Boc-Arg(Pbf)-OH provides a protected form of arginine that can be incorporated into peptide sequences through established coupling procedures.

It can support the preparation of research peptides, peptide fragments, and other arginine-containing structures for subsequent chemical and biological evaluation.

4.3 Peptide Intermediate and Pharmaceutical Research

Protected amino acids are essential starting materials in the development of peptide-based research compounds and pharmaceutical intermediates. Boc-Arg(Pbf)-OH offers a practical option for incorporating arginine into synthetic peptide structures while controlling functional group reactivity.

It is therefore relevant to peptide intermediate development, medicinal chemistry research, and the preparation of compounds for early-stage pharmaceutical investigations.

4.4 Protecting Group Chemistry and Peptide Process Development

The use of Boc and Pbf protecting groups provides an opportunity to study selective protection, deprotection, and peptide coupling strategies. Researchers and process chemists can use Boc-Arg(Pbf)-OH to investigate reaction conditions, coupling efficiency, purification procedures, and the preparation of arginine-containing peptide intermediates.

4.5 Custom Peptide Synthesis and Research Reagent Development

Boc-Arg(Pbf)-OH can be incorporated into custom peptide synthesis workflows where controlled amino acid protection is required. Its use may extend to peptide libraries, sequence modification studies, and the preparation of specialized peptide research materials.

5. Boc-Arg(Pbf)-OH Supply from Finetech Industry Limited

Finetech Industry Limited supplies Boc-Arg(Pbf)-OH (CAS 200124-22-7), with a specified purity of ≥98%, for peptide synthesis, pharmaceutical research, and specialty chemical applications.

Our available product supply options include:

1. Specified purity: ≥98%.
2. Physical appearance: White powder.
3. Flexible packaging: 100 g, 1 kg, 5 kg, and 25 kg.
4. Larger-scale supply: Production-scale quantities can be discussed according to customer requirements.
5. Storage guidance: Keep the product sealed, protect it from light, and store under refrigerated conditions.
6. Global shipping: International shipping arrangements are available for customers worldwide.

Whether you require research quantities for peptide development or larger quantities for process development and production, Finetech Industry Limited can support different purchasing and supply requirements.

6. Why Choose Finetech Industry Limited?

Finetech Industry Limited provides specialty chemicals, protected amino acids, peptide synthesis building blocks, and pharmaceutical research intermediates to customers worldwide.

Our services focus on:

1. A broad range of amino acid derivatives and peptide synthesis reagents.
2. Flexible packaging options for laboratory research and larger projects.
3. Scalable supply solutions for growing project requirements.
4. Professional support for product sourcing and chemical supply.
5. International shipping coordination for global customers.

We are committed to providing reliable chemical supply, responsive communication, and professional service to support long-term cooperation with research institutions, pharmaceutical companies, and chemical businesses.

7. Contact Finetech Industry Limited

For quotations, product availability, technical information, or bulk supply inquiries regarding Boc-Arg(Pbf)-OH (CAS 200124-22-7), please contact Finetech Industry Limited.

Product Number: FT-0650089

Product Name: Boc-Arg(Pbf)-OH

CAS Number: 200124-22-7

Purity: ≥98%

Packaging: 100 g / 1 kg / 5 kg / 25 kg

Supply Capability: Larger-scale production available

Website: https://www.finetechnology-ind.com/

Contact Finetech Industry Limited for product quotations and global supply arrangements.