Blebbistatin (CAS 856925-71-8): The Gold Standard Myosin II Inhibitor for Precision Research
In advanced life science research, the precision of your molecular tools dictates the reliability of your data. (-)-Blebbistatin (CAS No. 856925-71-8) is an essential, high-selectivity bioactive small molecule for scientists exploring the frontiers of cell biology, neuroscience, and mechanobiology.
Finetech Industry Limited specializes in supplying high-purity, research-grade (-)-Blebbistatin, ensuring your experiments are backed by consistent and reproducible results.
🔬 Chemical Profile & Specifications
The biological activity of Blebbistatin is highly dependent on its stereochemistry. As the active enantiomer, (-)-Blebbistatin offers superior potency compared to the racemic mixture.1
Property Specification
Chemical Name (-)-Blebbistatin
CAS Number 856925-71-8
Molecular Formula $C_{18}H_{16}N_{2}O_{2}$
Molecular Weight 292.33
Purity ≥98% (HPLC verified)
Solubility DMSO
⚙️ Mechanism of Action: How it Works
Unlike general inhibitors, (-)-Blebbistatin offers a sophisticated mode of action. It selectively targets non-muscle myosin II by stabilizing the myosin–ADP–Pi complex.
Force Inhibition: It prevents the power stroke, effectively "locking" the motor without detaching it from the actin.
Structural Integrity: It inhibits contractility without disrupting the underlying actin filament network.
Reversibility: Its effects can be washed out, allowing for dynamic, "start-stop" temporal studies of cellular tension.
🧬 Key Research Applications
1. Cell Biology & Cytoskeletal Dynamics
Investigate the fundamental forces of life. (-)-Blebbistatin is the preferred tool for studying:
Cytokinesis: Visualizing cell division and contractile ring formation.
Cell Migration: Understanding how cells crawl and adhere to 2D/3D matrices.
Morphology: Probing the relationship between actomyosin tension and cell shape.
2. Neuroscience & Developmental Biology
Mechanical tension is a primary driver of neural growth. Use this inhibitor to study:
Axon Guidance: How growth cones navigate through mechanical cues.
Synaptic Plasticity: The role of myosin in dendritic spine remodeling.
Morphogenesis: Tissue-level folding and development driven by cellular forces.
3. Mechanobiology & Tissue Engineering
In the era of organoids and "lab-on-a-chip" technology, controlling force is vital:
Traction Force Microscopy (TFM): Measuring the exact forces cells exert on substrates.
Stem Cell Differentiation: Exploring how substrate stiffness and internal tension dictate cell fate.
✅ Why Source from Finetech Industry Limited?
When you choose Finetech, you are choosing a partner dedicated to scientific excellence. Our (-)-Blebbistatin is characterized by:
Enantiomeric Purity: Guaranteed (-)-form for maximum biological efficacy.
Full Analytical Support: Every batch is shipped with NMR, MS, and HPLC reports.
Proven Stability: Optimized packaging to prevent light-sensitive degradation.
Global Logistics: Efficient, temperature-controlled shipping to research institutes and pharma labs worldwide
📖 Recommended References
Straight, A. F. et al. Dissecting temporal and spatial control of cytokinesis. Science, 2003.
Kovács, M. et al. Mechanism of blebbistatin inhibition of myosin II. JBC, 2004.
Even-Ram, S. et al. Myosin II regulates cell migration and adhesion dynamics. Nature Cell Biology, 2007.
🚀 Order Now for Your Next Project
Ready to elevate your mechanobiology research? Contact Finetech Industry Limited today for a quote or technical consultation.
Keywords: Myosin II Inhibitor, (-)-Blebbistatin, CAS 856925-71-8, Actomyosin contractility, Cell biology reagents, Mechanobiology tools, Finetech Industry Limited.