Product Code: FT-0605517

Product Name: 2-Pyrrolidinoethyl Chloride Hydrochloride

CAS Number: 7250-67-1

Molecular Formula: C₆H₁₃Cl₂N

Molecular Weight: 170.08 g/mol

Supplier: Finetech Industry Limited

1. Product Overview

2-Pyrrolidinoethyl chloride hydrochloride, also known as 1-(2-Chloroethyl)pyrrolidine hydrochloride or N-(2-Chloroethyl)pyrrolidine hydrochloride, is a nitrogen-containing heterocyclic building block used in organic synthesis and medicinal chemistry research. This compound combines a pyrrolidine ring with a two-carbon chloroethyl substituent, providing a functional structure for introducing pyrrolidinoethyl groups into suitable organic molecules.

The compound is particularly relevant to synthetic research involving substituted aromatic compounds, heterocyclic molecules, and pharmaceutical intermediates. Its chloroethyl functionality can participate in nucleophilic substitution reactions under appropriate conditions, allowing researchers to construct carbon–nitrogen or carbon–oxygen-linked molecular structures, depending on the reaction partner and synthetic strategy.

In medicinal chemistry, the introduction of a pyrrolidine-containing side chain can influence molecular properties such as basicity, aqueous behavior, and interactions with biological targets. Consequently, pyrrolidine-based structural motifs are frequently investigated during the design and optimization of biologically active molecules.

2. Chemical Identity and Common Synonyms

For accurate product identification, procurement, and scientific literature searches, the following names are commonly associated with CAS 7250-67-1:

1. 2-Pyrrolidinoethyl chloride hydrochloride
2. 1-(2-Chloroethyl)pyrrolidine hydrochloride
3. N-(2-Chloroethyl)pyrrolidine hydrochloride
4. 2-Chloroethylpyrrolidine hydrochloride
5. 1-(2-Chloroethyl)pyrrolidine hydrochloride
6. N-Chloroethylpyrrolidine hydrochloride
7. 2-Pyrrolidinoethyl chloride HCl

These names refer to the hydrochloride salt of the same compound. The salt has the molecular formula C₆H₁₃Cl₂N and a molecular weight of approximately 170.08 g/mol. Supplier databases and chemical catalogs use these alternative names for product identification and ordering.

3. Applications in Organic Synthesis

3.1 Introduction of Pyrrolidinoethyl Side Chains

One important synthetic application of 2-pyrrolidinoethyl chloride hydrochloride is the introduction of a pyrrolidinoethyl substituent into suitable molecular scaffolds. In a typical substitution-based transformation, the chloroethyl group serves as a reactive handle, while an appropriate nucleophile provides the complementary reaction site.

Depending on the substrate, reaction conditions, and functional groups present, this chemistry may be used to prepare compounds containing ether or related nitrogen-containing side chains. Such transformations are valuable when researchers need to modify an existing molecular scaffold without rebuilding the entire structure.

The pyrrolidine ring also provides a compact, saturated nitrogen-containing structural unit. Its incorporation can be useful in systematic studies of molecular structure, physicochemical properties, and structure–activity relationships.

3.2 O-Alkylation of Phenolic and Heteroaromatic Compounds

A documented application involves the synthesis of pyrrolidinoethoxy-substituted aromatic compounds. In a study published in the Journal of Medicinal Chemistry in 1989, researchers reported the preparation of a benzofuran derivative bearing a pyrrolidinoethoxy substituent using 2-pyrrolidinoethyl chloride hydrochloride in the presence of potassium carbonate in acetone under reflux conditions.

This example demonstrates the compound's practical role as an alkylating reagent in the modification of phenolic molecular scaffolds. Related substitution chemistry can support the preparation of functionalized aromatic and heteroaromatic compounds for further medicinal chemistry investigations.

Literature reference: Journal of Medicinal Chemistry (1989), volume 32, issue 8, article on the structure–activity relationships of antiestrogens. The reported synthesis of a pyrrolidinoethoxy-substituted benzofuran illustrates the use of this reagent in medicinal chemistry.

3.3 Pharmaceutical Intermediate Development

In pharmaceutical research, the preparation of structurally diverse intermediates is an important stage in the discovery and optimization of candidate molecules. 2-Pyrrolidinoethyl chloride hydrochloride can serve as a synthetic building block when a target structure requires a pyrrolidine-containing side chain.

Potential research applications include:

1. Preparation of substituted aromatic and heteroaromatic intermediates.
2. Functionalization of phenolic compounds through ether formation.
3. Synthesis of nitrogen-containing molecular libraries.
4. Exploration of substituent effects in medicinal chemistry.
5. Development of intermediates for subsequent chemical transformations.

The suitability of this reagent depends on the target structure, reaction compatibility, and the required purity of the resulting intermediate. Its use as a building block does not, by itself, establish that the compound has any particular therapeutic activity.

4. Relevance to Medicinal Chemistry and Structure–Activity Relationship Studies

Pyrrolidine is a saturated nitrogen-containing heterocycle widely used in medicinal chemistry. Pyrrolidine-containing substituents can contribute to molecular conformational preferences, basicity, solubility behavior, and target-binding characteristics. These properties depend on the complete molecular structure and cannot be predicted from the presence of the ring alone.

Researchers may use 2-pyrrolidinoethyl chloride hydrochloride to prepare analogues with different aromatic cores or functional groups. Such analogue synthesis can support structure–activity relationship (SAR) studies, in which chemical modifications are compared to determine their effects on biological activity and molecular properties.

For example, introducing a pyrrolidinoethoxy substituent onto an aromatic scaffold can provide a means of investigating how side-chain architecture influences the properties of a compound series. Any biological conclusions, however, must be established through appropriate experimental testing.

The compound is therefore best described as a synthetic research intermediate, rather than as an active pharmaceutical ingredient or a biologically active agent in its own right.

5. Research and Quality Considerations

When selecting 2-pyrrolidinoethyl chloride hydrochloride for laboratory or process-development work, researchers should consider identity confirmation, purity, moisture sensitivity, and compatibility with the intended reaction.

Relevant quality-control considerations may include:

1. Chemical identity confirmation using appropriate analytical methods.
2. Purity determination using a validated method.
3. Assessment of residual moisture where relevant.
4. Verification of appearance and other specification parameters.
5. Review of the current safety data sheet before handling and storage.

Commercial specifications may differ between suppliers and batches. Researchers should consult the relevant certificate of analysis (COA) and product specification rather than assuming that all products sold under the same chemical name have identical quality attributes.

6. Product Supply from Finetech Industry Limited

Finetech Industry Limited supplies 2-Pyrrolidinoethyl chloride hydrochloride (CAS 7250-67-1) for research, organic synthesis, and pharmaceutical intermediate development.

Product identification details:

1. Product Code: FT-0605517
2. CAS Number: 7250-67-1
3. Molecular Formula: C₆H₁₃Cl₂N
4. Molecular Weight: 170.08 g/mol
5. Product Category: Research Building Blocks and Pharmaceutical Intermediates

Finetech Industry Limited supports customers working in medicinal chemistry, synthetic organic chemistry, and chemical process development. For current availability, batch-specific specifications, analytical documentation, packaging options, and larger-volume requirements, customers may contact Finetech Industry Limited directly.

Supply quantities and lead times are subject to confirmation based on inventory, production arrangements, and order requirements.

7. Frequently Asked Questions

What is 2-Pyrrolidinoethyl chloride hydrochloride?

It is a nitrogen-containing heterocyclic compound used as a synthetic building block in organic synthesis and medicinal chemistry research.

What is the CAS number of 2-Pyrrolidinoethyl chloride hydrochloride?

The CAS Registry Number is 7250-67-1.

What are the alternative names for this compound?

Common names include 1-(2-Chloroethyl)pyrrolidine hydrochloride, N-(2-Chloroethyl)pyrrolidine hydrochloride, and 2-Chloroethylpyrrolidine hydrochloride.

What is this compound used for?

Its documented applications include the preparation of pyrrolidinoethyl-substituted aromatic compounds and pharmaceutical research intermediates, particularly in substitution-based organic synthesis.

Is 2-Pyrrolidinoethyl chloride hydrochloride an API?

It is generally supplied as a chemical intermediate or research building block. It should not be described as an API without product-specific evidence.

Can Finetech Industry Limited supply this product in larger quantities?

Finetech can discuss larger-volume supply requirements, subject to confirmation of stock, production capacity, specifications, and delivery arrangements.

8. References

Journal of Medicinal Chemistry. 1989, 32(8). Structure–Activity Relationship of Antiestrogens. The published synthetic work includes an example using 2-pyrrolidinoethyl chloride hydrochloride to prepare a pyrrolidinoethoxy-substituted benzofuran derivative.

About Finetech Industry Limited

Finetech Industry Limited provides research chemicals, specialty chemical building blocks, pharmaceutical intermediates, and custom synthesis services for scientific research and chemical development. The company supports customers with product sourcing and supply solutions for laboratory research, process development, and larger-scale chemical requirements.

For product inquiries, specifications, or bulk supply requests, contact Finetech Industry Limited.