(R)-(+)-2-Tetrahydrofuroic Acid CAS 87392-05-0 | High Purity Supplier & Bulk Manufacturer

(R)-(+)-2-Tetrahydrofuroic acid, also known as (R)-(+)-Tetrahydrofuran-2-carboxylic acid, is a chiral carboxylic acid building block widely used in pharmaceutical synthesis and asymmetric organic chemistry. With CAS number 87392-05-0 and the molecular formula C5H8O3, it is one of the most important single-enantiomer intermediates derived from the tetrahydrofuran ring system.

Because of its defined (R)-configuration and high enantiomeric purity, (R)-(+)-2-Tetrahydrofuroic acid is commonly used as a chiral intermediate for active pharmaceutical ingredients, a resolving agent, and a starting material for new drug candidates. It is a key raw material in the manufacture of the beta-lactam antibiotic Faropenem sodium, the influenza antiviral Baloxavir Marboxil, and the antihypertensive agent Terazosin.

Finetech Industry Limited manufactures and supplies high-purity (R)-(+)-2-Tetrahydrofuroic acid (CAS 87392-05-0) with a chemical purity of 98% and enantiomeric excess (ee) of 99%. Supply capacities range from gram quantities for laboratory research to kilogram and bulk production. Every batch is manufactured under strict quality control and supplied with a comprehensive Certificate of Analysis (COA), ensuring consistent purity, verified chirality and traceability.

Specifications

Applications

Pharmaceutical Intermediate and API Building Block

(R)-(+)-2-Tetrahydrofuroic acid is primarily used as a chiral pharmaceutical intermediate. Its single-enantiomer structure is valuable for producing optically active drug molecules where stereochemistry directly affects biological activity. Reported pharmaceutical applications include:

1. Synthesis of Faropenem sodium, an oral beta-lactam antibiotic
2. Synthesis of Baloxavir Marboxil, an influenza antiviral agent
3. Synthesis of Terazosin, an antihypertensive and BPH drug
4. Intermediate for anticancer drug candidates
5. Building block for other chiral active pharmaceutical ingredients

High enantiomeric purity is essential for these applications, which is why the 99% ee grade is preferred by pharmaceutical manufacturers.

Chiral Building Block and Asymmetric Synthesis

As an enantiopure carboxylic acid, it is a versatile chiral building block in asymmetric synthesis. Typical uses include:

1. Chiral resolving agent for separating racemic mixtures
2. Chiral auxiliary in stereoselective reactions
3. Ligand precursor for asymmetric catalysis
4. Starting material for chiral esters, amides and alcohols
5. Construction of tetrahydrofuran-containing target molecules

Research and Method Development

Research institutions and analytical laboratories use it as a reference material and model substrate for chiral HPLC method development, enantiomeric purity determination, reaction mechanism studies, and process chemistry route scouting.

Bulk Supply

Finetech Industry Limited supplies (R)-(+)-2-Tetrahydrofuroic acid for both research and industrial requirements, from gram quantities and 10 g, 25 g, 100 g, 500 g, 1 kg, through multi-kilogram and bulk production. Each shipment includes a Certificate of Analysis (COA), chiral purity (ee) report, Safety Data Sheet (SDS), batch traceability and secure protective packaging. Customized packaging and labeling are available upon request.

Storage and Handling

Store in a cool, dry, well-ventilated area in tightly closed containers, protected from moisture and strong oxidizing agents. A storage temperature of 2 to 8 C is recommended for long-term stability of the enantiomeric purity. Handle with standard laboratory personal protective equipment.

Why Choose Finetech Industry Limited

1. High purity (R)-(+)-2-Tetrahydrofuroic acid, 98% assay with 99% ee
2. Consistent batch-to-batch quality and verified chirality
3. Comprehensive analytical documentation, including chiral HPLC
4. Flexible packaging from gram to bulk quantities
5. Fast and reliable global delivery
6. Technical support from experienced specialists
7. Competitive pricing for laboratory and industrial customers

Frequently Asked Questions

What is the CAS number of (R)-(+)-2-Tetrahydrofuroic acid?

The CAS Registry Number is 87392-05-0.

What is the molecular formula and molecular weight?

The molecular formula is C5H8O3 and the molecular weight is 116.11 g/mol.

What purity and enantiomeric excess are available?

Finetech Industry Limited supplies it with a minimum chemical purity of 98% and a minimum enantiomeric excess (ee) of 99%, verified by HPLC, chiral HPLC, GC, NMR and MS.

What does it look like?

It is a colorless liquid at room temperature.

What is it used for?

It is mainly used as a chiral pharmaceutical intermediate for products such as Faropenem sodium, Baloxavir Marboxil and Terazosin, and as a chiral building block in asymmetric synthesis.

Can you supply bulk quantities?

Yes. Finetech manufactures it from laboratory scale to multi-kilogram and bulk quantities for pharmaceutical and industrial customers.

Do you provide analytical documentation?

Yes. Every shipment includes a COA, chiral purity (ee) report, SDS and batch traceability information.

Request a Quote for (R)-(+)-2-Tetrahydrofuroic Acid CAS 87392-05-0

High-purity (R)-(+)-2-Tetrahydrofuroic acid (98%, 99% ee) for pharmaceutical manufacturers, research laboratories and industrial applications worldwide. Please provide required quantity, purity/ee and destination country for a fast quote.

Email: [email protected]   |   Web: www.finetechnology-ind.com